Honey combination treatments for skin infections and wounds.

Topical application of medical grade honey is recommended for clinical treatment of wound infections. The suitability of honey as a wound healing agent is largely due to its antibacterial activity, immunomodulatory properties and biocompatibility.

Despite the usefulness of honey in wound healing, chronic infections continue to be a global problem that requires new and better therapeutic interventions. Several recent studies have investigated the effects of combining honey with other therapies in order to find more effective treatments. In research, it was found that synergistic antimicrobial effects or additives were observed in vitro when honey was combined with antibiotics, bacteriophages, antimicrobial peptides, natural agents, for example, ginger or propolis and other treatment approaches, as the use of chitosan hydrogel.

The results depend on the type of honey, the combination agent or the treatment and the microbial species. Improved wound healing was also observed in vivo in rats when honey was combined with laser therapy or Bacteriophage therapy. More clinical studies in humans are needed to fully understand the effectiveness of honey combination therapies for the treatment of skin and wound infections.

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